Each year in the U.S., 27,000 men and women get cancer caused by human papillomavirus (HPV). HPV vaccination is the most effective way to prevent these painful or deadly illnesses. HPV vaccine is recommended for boys and girls at 11–12 years of age, when HPV acquisition is low and the immune response to the vaccine is more robust. Unfortunately, New York City’s HPV vaccination rates fall dramatically short of the 2020 national goal of 80 percent three-dose coverage. Health care providers play a critical role in increasing HPV vaccination rates, and this toolkit offers helpful strategies and tools.